Tumor-Associated Macrophages in Vestibular Schwannoma and Relationship to Hearing.

Eric S NisenbaumCarly MisztalMikhaylo SzczupakTorin ThielhelmStefanie PeñaChristine MeiStefania GoncalvesOlena BrachoRuixuan MaMichael E IvanJacques MorcosFred TelischiXue-Zhong LiuCristina Fernandez-ValleChristine T Dinh

Published in: OTO open (2021)

Vestibular schwannomas express varying degrees of CD80+ M1 and CD163+ M2 macrophages. We present evidence that higher expression of CD163+ may contribute to poorer hearing outcomes in patients with VS. We also describe in vitro assays in a proof-of-concept investigation that VS cells can initiate monocyte migration and macrophage polarization. Future investigations are warranted to explore the relationships between tumor, macrophages, secreted cytokines, and hearing outcomes in patients with VS.

Keyphrases

hearing loss
induced apoptosis
poor prognosis
nk cells
type diabetes
high throughput
immune response
endothelial cells
oxidative stress
cell proliferation
adipose tissue
binding protein
metabolic syndrome
weight loss