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Genetic screening and functional analysis of CASP9 mutations in a Chinese cohort with neural tube defects.

Xiao-Zhen LiuQin ZhangQian JiangBao-Ling BaiXiao-Juan DuFang WangLi-Hua WuXiao-Lin LuYi-Hua BaoHui-Li LiTing Zhang
Published in: CNS neuroscience & therapeutics (2018)
Our findings identify a genetic link for apoptosis in human NTDs and highlight the effect of gene-environment interactions in a complex disease.
Keyphrases
  • genome wide
  • copy number
  • oxidative stress
  • dna methylation
  • endoplasmic reticulum stress
  • cell death
  • cell cycle arrest
  • pluripotent stem cells
  • gene expression