Clinicopathological Significance of FOXO4 Expression and Correlation with Prx1 in Head and Neck Squamous Cell Carcinoma.

Yunping LuYajun ShenLingyu LiMin ZhangMin WangLihua GeJing Yang Xiaofei Tang

Published in: Analytical cellular pathology (Amsterdam) (2021)

FOXO4 plays an important role in the development of HNSCC. The lower expression of FOXO4 is significantly correlated with the shorter OS in patients with HNSCC. FOXO4 is negatively regulated via interaction with Prx1. FOXO4 could be a potential molecular target for the treatment and prognosis of HNSCC.

Keyphrases

transcription factor
pi k akt
signaling pathway
poor prognosis
binding protein
risk assessment
combination therapy
smoking cessation