Comparative regulomics supports pervasive selection on gene dosage following whole genome duplication.

Gareth B GillardLars GrønvoldLine L RøsægMatilde Mengkrog HolenØystein MonsenBen F KoopEric B RondeauManu Kumar GundappaJohn MendozaDaniel J MacqueenRori V RohlfsSimen R SandveTorgeir R Hvidsten

Published in: Genome biology (2021)

Our results imply pervasive adaptive expression evolution following WGD to overcome the immediate challenges posed by genome doubling and to exploit the long-term genetic opportunities for novel phenotype evolution.

Keyphrases

genome wide
copy number
poor prognosis
dna methylation
binding protein
transcription factor