Medical cannabis or cannabinoids for chronic non-cancer and cancer related pain: a systematic review and meta-analysis of randomised clinical trials.
Li WangPatrick J HongCurtis MayYasir RehmanYvgeniy OparinChris J HongBrian Y HongMahmood AminiLariLucas GalloAlka KaushalSamantha CraigieRachel J CoubanElena KumHarsha ShanthannaIra PriceSuneel UpadhyeMark A WareFiona CampbellRachelle BuchbinderThomas AgoritsasJason W BussePublished in: BMJ (Clinical research ed.) (2021)
Moderate to high certainty evidence shows that non-inhaled medical cannabis or cannabinoids results in a small to very small improvement in pain relief, physical functioning, and sleep quality among patients with chronic pain, along with several transient adverse side effects, compared with placebo. The accompanying BMJ Rapid Recommendation provides contextualised guidance based on this body of evidence. SYSTEMATIC REVIEW REGISTRATION: https://osf.io/3pwn2.
Keyphrases
- chronic pain
- sleep quality
- clinical trial
- systematic review
- pain management
- healthcare
- double blind
- physical activity
- depressive symptoms
- open label
- papillary thyroid
- meta analyses
- mental health
- phase iii
- neuropathic pain
- cystic fibrosis
- placebo controlled
- study protocol
- phase ii
- randomized controlled trial
- high intensity
- lymph node metastasis
- spinal cord injury
- adverse drug
- loop mediated isothermal amplification
- drug induced
- brain injury