Association between 21-gene-assay and detection of disseminated tumor cells in patients with early breast cancer: results from the IRMA trial.

Lea Louise VolmerDominik DannehlTobias EnglerMarkus HahnChristina B WalterMarkus WallwienerSara Y BruckerFlorin-Andrei TaranAndreas D Hartkopf

Published in: Breast cancer research and treatment (2023)

We therefore confirm that a high genomic risk is associated with tumor cell dissemination into the BM. Further trials are needed to investigate whether therapeutic decisions could be further individualized by combining DTC-status and prognostic gene signature testing.

Keyphrases

copy number
early breast cancer
genome wide
genome wide identification
single cell
clinical trial
study protocol
cell therapy
phase iii
randomized controlled trial
dna methylation
gene expression
stem cells
transcription factor
genome wide analysis
breast cancer risk
placebo controlled