Population Pharmacokinetic Properties of Piperaquine in Falciparum Malaria: An Individual Participant Data Meta-Analysis.
Richard M HoglundLesley WorkmanMichael D EdsteinNguyen Xuan ThanhNguyen Ngoc QuangIssaka ZongoJean Bosco OuedraogoSteffen BorrmannLeah MwaiChristian NsanzabanaRichard N PricePrabin DahalNancy C SambolSunil ParikhFrancois H NostenElizabeth A AshleyAung Pyae PhyoKhin Maung LwinRose McGreadyNicholas P J DayPhilippe J GuerinNicholas J WhiteKaren I BarnesJoel TarningPublished in: PLoS medicine (2017)
The derived population pharmacokinetic model was used to develop a revised dose regimen of dihydroartemisinin-piperaquine that is expected to provide equivalent piperaquine exposures safely in all patients, including in small children with malaria. Use of this dose regimen is expected to prolong the useful therapeutic life of dihydroartemisinin-piperaquine by increasing cure rates and thereby slowing resistance development. This work was part of the evidence that informed the World Health Organization technical guidelines development group in the development of the recently published treatment guidelines (2015).