Factors Associated with Poststroke Anxiety: A Systematic Review and Meta-Analysis.
Francesca WrightSimiao WuHo-Yan Yvonne ChunGillian Elizabeth MeadPublished in: Stroke research and treatment (2017)
Background and Purpose. Anxiety affects 25% of stroke survivors. There are no effective treatments. Poststroke depression, prestroke anxiety and depression, locus of control, coping, confidence, fatigue, and sleep are factors that may be associated with poststroke anxiety and can potentially be targeted by therapy. We systematically reviewed the literature and performed a meta-analysis to identify associations with these factors. Methods. We searched electronic databases from January 2014 to July 2015 to complement a literature search performed from inception to May 2014. Study quality was assessed using an internationally endorsed checklist. We used odds ratios (ORs) to estimate the strength of associations and random-effects modelling to calculate summary effect sizes. Results. There were 24 studies recruiting 15448 patients. Quality of reporting was satisfactory. 13 studies with 2408 patients reported associations between poststroke anxiety and poststroke depression (OR = 4.66, 95% confidence interval: 2.23, 9.74). One study reported association with prestroke anxiety, three with prestroke depression, one with fatigue, and two with sleep. No studies reported on locus of control, coping, or confidence. Conclusion. Poststroke anxiety was associated with depression but there are limited data on other modifiable associations. Further research is needed to identify potential targets for treatment.
Keyphrases
- sleep quality
- depressive symptoms
- end stage renal disease
- upper limb
- physical activity
- newly diagnosed
- ejection fraction
- systematic review
- chronic kidney disease
- social support
- peritoneal dialysis
- emergency department
- atrial fibrillation
- case control
- mesenchymal stem cells
- patient reported outcomes
- quality improvement
- drug delivery
- blood brain barrier
- climate change
- machine learning
- brain injury
- combination therapy
- adverse drug
- cell therapy
- replacement therapy