Sjögren Syndrome without Focal Lymphocytic Infiltration of the Salivary Glands.
Rohan SharmaKaustubh S ChaudhariBiji T KurienKiely GrundahlLida RadfarDavid M LewisChristopher J LessardHe LiAstrid RasmussenKathy L SivilsRobert Hal ScofieldPublished in: The Journal of rheumatology (2019)
There are only a few clinical differences between patients with primary SS with focus score zero and those with both anti-Ro and a focus score > 1.0. The small subset of focus score zero patients tested did not have elevated expression of IFN-regulated genes, but did have systemic disease. Thus, extraglandular manifestations are perhaps more related to the presence of anti-Ro than increased IFN. This may have relevance to pathogenesis of SS.