Metformin enhances LDL-cholesterol uptake by suppressing the expression of the pro-protein convertase subtilisin/kexin type 9 (PCSK9) in liver cells.

Amjad AliHema UnnikannanJasmin ShafarinKhuloud BajboujJalal TaneeraJibran Sualeh MuhammadHaydar HasanAlbert SalehiSamir AwadallahMawieh Hamad

Published in: Endocrine (2022)

These findings suggest that MF treatment reduces circulating LDL-C levels by suppressing PCSK9 expression and enhancing LDLR expression; hence the potential therapeutic utility of MF in hypercholesterolemia.

Keyphrases

low density lipoprotein
poor prognosis
binding protein
induced apoptosis
long non coding rna
cell cycle arrest