Severe Fatigue and Persistent Symptoms at Three Months Following SARS-CoV-2 Infections During the Pre-Delta, Delta, and Omicron Time Periods: A Multicenter Prospective Cohort Study.
Micheal GottliebRalph WangHuihui YuErica S SpatzJuan Carlos MontoyRobert RodriguezAnna Marie ChangJoann G ElmorePaavali A HannikainenMandy HillRyan M HuebingerAhamed H IdrisZhenqiu LinKatherine KooSamuel McDonaldKelli N O'LaughlinIan D PlumbMichelle SantangeloSharon SaydahMichael WillisLauren E WiskArjun K VenkateshKari A StephensRobert A Weinsteinnull nullPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2023)
Prolonged symptoms following SARS-CoV-2 infection were more common among participants infected during the pre-Delta period compared with Delta and Omicron periods; however, these differences were no longer significant after adjusting for vaccination status. This suggests a potential beneficial effect of vaccination on the risk of developing long-term symptoms.