An "EZ" Epigenetic Road to Leukemia Stem Cell Metabolic Reprogramming?
Ari M MelnickAri M MelnickPublished in: Cancer discovery (2019)
In this issue of Cancer Discovery, Gu and colleagues developed a mouse model of myeloproliferative neoplasm driven by Nras G12D and Ezh2-/- , which cooperated to induce malignant transformation and metabolic reprogramming of leukemic stem cells at least in part through loss of normal epigenetic regulation of gene expression. Furthermore, their findings point to Ezh1 and branched chain amino acid metabolism as biological dependencies and potential therapeutic targets in myeloid neoplasms.See related article by Gu et al., p. 1228.
Keyphrases
- stem cells
- gene expression
- acute myeloid leukemia
- mouse model
- dna methylation
- amino acid
- bone marrow
- papillary thyroid
- long noncoding rna
- long non coding rna
- small molecule
- cell therapy
- dendritic cells
- high throughput
- squamous cell carcinoma
- low grade
- squamous cell
- human health
- immune response
- lymph node metastasis
- climate change
- childhood cancer
- drug induced