Task Learning Promotes Plasticity of Interneuron Connectivity Maps in the Olfactory Bulb.
Longwen HuangKevin UngIsabella GarciaKathleen B QuastKeith CordinerPeter SaggauBenjamin R ArenkielPublished in: The Journal of neuroscience : the official journal of the Society for Neuroscience (2017)
Deducing how specific interneuron subtypes contribute to normal circuit function requires understanding the dynamics of their connections. In the olfactory bulb (OB), diverse interneuron subtypes vastly outnumber principal excitatory cells. By combining acousto-optic deflector-based scanning microscopy, electrophysiology, and genetically targeted expression of Channelrhodopsin-2, we mapped the functional connectivity between mitral cells (MCs) and OB interneurons in a cell-type-specific manner. We found that, whereas external plexiform layer (EPL) interneurons show broadly distributed patterns of stable connectivity with MCs, adult-born granule cells show dynamic and plastic patterns of synaptic connectivity with task learning. Together, these findings reveal the diverse roles for interneuons within sensory circuits toward information learning and processing.
Keyphrases
- functional connectivity
- resting state
- induced apoptosis
- cell cycle arrest
- white matter
- high resolution
- endoplasmic reticulum stress
- heart failure
- poor prognosis
- cell death
- optical coherence tomography
- mitral valve
- oxidative stress
- cell proliferation
- high throughput
- single molecule
- single cell
- coronary artery disease
- dna methylation
- aortic valve
- high speed
- prefrontal cortex