Reduced Cerebrospinal Fluid Levels of Lysophosphatidic Acid Docosahexaenoic Acid in Patients With Major Depressive Disorder and Schizophrenia.

Wataru OmoriKuniyuki KanoKotaro HattoriNaoto KajitaniMami Okada-TsuchiokaShuken BokuHiroshi KunugiJunken AokiMinoru Takebayashi

Published in: The international journal of neuropsychopharmacology (2022)

The lower levels of LPA 22:6 in patients with MDD and SCZ suggest an abnormality of LPA 22:6 metabolism. In addition, several depressive symptoms in patients with MDD were significantly associated with the lower levels of LPA 22:6, suggesting an involvement of LPA 22:6 in the pathophysiology of MDD.

Keyphrases

major depressive disorder
bipolar disorder
depressive symptoms
cerebrospinal fluid
fatty acid
sleep quality