A nonmyeloablative chimeric mouse model accurately defines microglia and macrophage contribution in glioma.

K YuA S YoushaniF L WilkinsonC O'LearyP CookL LaanisteA LiaoD MossesC WaughH ShorrockO PathmanabanA MacdonaldI Kamaly-AslF RoncaroliBrian W Bigger

Published in: Neuropathology and applied neurobiology (2018)

NMT is a powerful method for dissecting tumour microglia and macrophage subpopulations and can guide further investigation of BMDC subsets in glioma and neuro-inflammatory diseases.

Keyphrases

mouse model
inflammatory response
adipose tissue
neuropathic pain
cell therapy
oxidative stress
peripheral blood
stem cells
spinal cord
mesenchymal stem cells