Human Wharton's jelly-derived mesenchymal stem cells alleviate concanavalin A-induced fulminant hepatitis by repressing NF-κB signaling and glycolysis.
Lijie PanChang LiuQiuli LiuYanli LiCong DuXinmei KangShuai DongZhuowei ZhouHuaxin ChenXiaoqi LiangJiajie ChuYan XuQi ZhangPublished in: Stem cell research & therapy (2021)
In summary, our data confirmed the potent therapeutic role of MSCs-derived from Wharton's jelly of human umbilical cord on Con A-induced fulminant hepatitis, and uncovered new mechanisms that glycolysis metabolic shift mediates suppression of T cell immunity by hWJ-MSCs.
Keyphrases
- umbilical cord
- mesenchymal stem cells
- endothelial cells
- high glucose
- diabetic rats
- bone marrow
- induced pluripotent stem cells
- signaling pathway
- pluripotent stem cells
- oxidative stress
- liver failure
- pi k akt
- big data
- lps induced
- immune response
- cell proliferation
- nuclear factor
- toll like receptor
- stress induced
- inflammatory response