Efficacy of oral and topical antioxidants in the prevention and management of oral mucositis in head and neck cancer patients: a systematic review and meta-analyses.
Afsheen RazaNelli KarimyanAmber L WattersChitra Priya EmperumalKamal Al-EryaniReyes EncisoPublished in: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer (2022)
Though oral and topical antioxidants significantly improved mucositis severity scores in HNC patients receiving radiotherapy with/without chemotherapy in individual studies, the quality of the evidence was low due to the small number of studies and unclear/high-risk bias. Additionally, large RCTs are needed to confirm these results.
Keyphrases
- radiation induced
- end stage renal disease
- meta analyses
- locally advanced
- systematic review
- ejection fraction
- newly diagnosed
- chronic kidney disease
- early stage
- radiation therapy
- prognostic factors
- case control
- randomized controlled trial
- chemotherapy induced
- peritoneal dialysis
- wound healing
- quality improvement
- patient reported