Diagnostic Value and Molecular Function of MicroRNAs in Endometrial Diseases: A Systematic Review.
Natalia KluzEmilia KowalczykMałgorzata WasilewskaPaulina Gil-KulikPublished in: Cancers (2024)
The human endometrium experiences significant cyclic morphological and biochemical changes throughout the menstrual cycle to prepare for embryo implantation. These processes are meticulously regulated by ovarian steroids and various locally expressed genes, encompassing inflammatory reactions, apoptosis, cell proliferation, angiogenesis, differentiation (tissue formation), and tissue remodeling. MicroRNAs (miRNAs) have been recognized as crucial regulators of gene expression, with their altered expression being linked to the onset and progression of various disorders, including cancer. This review examines the expression of miRNAs in the endometrium and their potential regulatory roles under pathological conditions such as endometriosis, recurrent implantation failure and endometrial cancer. Given miRNAs' critical role in maintaining gene expression stability, understanding the regulatory mechanisms of endometrial miRNAs and identifying their specific target genes could pave the way for developing preventive and therapeutic strategies targeting specific genes associated with these reproductive disorders.
Keyphrases
- endometrial cancer
- gene expression
- poor prognosis
- endothelial cells
- cell proliferation
- transcription factor
- dna methylation
- oxidative stress
- genome wide
- genome wide identification
- cell cycle
- papillary thyroid
- endoplasmic reticulum stress
- binding protein
- cell death
- cell cycle arrest
- risk assessment
- pregnant women
- vascular endothelial growth factor
- squamous cell
- cancer therapy
- pi k akt
- drug delivery
- induced pluripotent stem cells
- wound healing