Increasing frequency of gene copy number aberrations is associated with immunosuppression and predicts poor prognosis in gastric adenocarcinoma.
Arnaldo N S SilvaYuichi SaitoTakaki YoshikawaTakashi OshimaJeremy D HaydenJan OostingSophie EarleLindsay C HewittHayley L SlaneyAlexander I WrightImran InamRuth E LangleyWilliam AllumMatthew G NankivellGordon G A HutchinsDavid CunninghamHeike I GrabschPublished in: The British journal of surgery (2022)
CIN may be a potential new prognostic biomarker independent of pTNM stage in gastric cancer. Patients with gastric cancer demonstrating CIN appear to be immunosuppressed, which might represent one of the underlying mechanisms explaining the poor survival and may help guide future therapeutic decisions.