Attenuation of chronic tension headache frequency and severity with daily L-arginine and aged garlic extract dietary supplementation.
Devahuti ChalihaMauro VaccarezzaVirginie LamRyusuke TakechiJohn C L MamoPublished in: European journal of clinical nutrition (2021)
A 74-year-old female subject with suboptimal management of episodic tension headache was treated with a daily dose of 1.5 g L-arginine and 1.2 g aged garlic extract (AGE). The aim of the intervention was to promote vasodilation of parenchymal cerebral blood vessels. Within 6 weeks of commencing treatment, her self-reported symptoms improved markedly and were sustained at 2 years following commencement. We propose that the putative beneficial effect of L-arginine and AGE in this patient is because of the well-established systemic vasodilatory effects of L-arginine and aged garlic extract. On the hypothesis that migraine is precipitated by cerebral microvascular constriction, we recommend a double-blind randomised controlled trial to clinically test this hypothesis in migraine patients.
Keyphrases
- nitric oxide
- oxidative stress
- end stage renal disease
- newly diagnosed
- subarachnoid hemorrhage
- randomized controlled trial
- amino acid
- anti inflammatory
- ejection fraction
- chronic kidney disease
- physical activity
- study protocol
- brain injury
- patient reported outcomes
- clinical trial
- spinal cord
- spinal cord injury
- cerebral ischemia
- cerebral blood flow
- drug induced
- blood brain barrier
- finite element