All-Trans Retinoic Acid Induces CD4+CD25+FOXP3+ Regulatory T Cells by Increasing FOXP3 Demethylation in Systemic Sclerosis CD4+ T Cells.

Xiaohong SunYangfan XiaoZhuotong ZengYaqian ShiBingsi TangHai LongTakuro KanekuraJiucun WangHaijing WuMing ZhaoQianjin LuRong Xiao

Published in: Journal of immunology research (2018)

ATRA acts as an inducer of Treg response in SSc CD4+ T cells via demethylation of the FOXP3 promoter and activation of FOXP3 expression. This may be one of the molecular mechanisms for ATRA, and therefore, RA can be used for the treatment of SSc.

Keyphrases

regulatory t cells
systemic sclerosis
interstitial lung disease
dendritic cells
poor prognosis
rheumatoid arthritis
gene expression
transcription factor
immune response