Rapamycin Exacerbates Staphylococcus aureus Pneumonia by Inhibiting mTOR-RPS6 in Macrophages.

Fang-Yi YuKua ZhengYin-Fang WuShen-Wei GaoQing-Yu WengChen ZhuYan-Ping WuMiao LiZhong-Nan QinJia-Fei LouZhi-Hua ChenSong-Min YingHua-Hao ShenWen Li

Published in: Journal of inflammation research (2023)

pneumonia by increasing the inflammatory levels of macrophages. Inhibition of mTOR-RPS6 pathway upregulates the expression of cytokines and chemokines in macrophages, thus increases inflammatory cells infiltration and exacerbates tissue damage.

Keyphrases

staphylococcus aureus
oxidative stress
induced apoptosis
cell proliferation
poor prognosis
cell cycle arrest
escherichia coli
biofilm formation
cell death
long non coding rna