Four-parameter analysis in modified Rotarod test for detecting minor motor deficits in mice.
Hui-Min ShanMichael A MaurerMartin E SchwabPublished in: BMC biology (2023)
These results show that by making adjustments to the protocol and employing a more refined analysis, it is possible to expand a widely used routine behavioral test with additional accessible parameters that detect relevant deficits in a model of mild to moderate traumatic brain injury. The modified Rotarod test maybe a valuable tool for better preclinical evaluations of drugs and therapies.