Blocking GPR15 Counteracts Integrin-dependent T Cell Gut Homing in Vivo.
Sebastian SchrammLi-Juan LiuMarek SaadLisa DietzMark DeddenTanja M MüllerImke AtreyaCaroline J VoskensGisela FeltenMarkus F NeurathSebastian ZundlerPublished in: Journal of Crohn's & colitis (2024)
GPR15 seems to have a broad, but organ-selective, impact on T cell trafficking and is therefore a promising target for future therapy of IBD. Further studies are needed.