Effectiveness of acyclovir prophylaxis against varicella zoster virus disease after allogeneic hematopoietic cell transplantation: A systematic review and meta-analysis.

Yuko Wada-Shimosato Reo TanoshimaKanako HiratokoMasanobu TakeuchiShin-Ichi TsujimotoNorio ShibaShinya ItoTakeharu YamanakaShuichi Ito

Published in: Transplant infectious disease : an official journal of the Transplantation Society (2019)

This study showed that acyclovir prophylaxis reduced VZV infection after HCT with no fatal cases and acyclovir prophylaxis is beneficial. No significant adverse effects occurred and no delayed VZV disease was identified.

Keyphrases

herpes simplex virus
stem cell transplantation
randomized controlled trial
systematic review
bone marrow
high dose
signaling pathway