Role of High-Dose Adjuvant Chemotherapy Followed by Autologous Stem Cell Transplantation in Locally Advanced Triple-Negative Breast Cancer: A Retrospective Chart Review.
Bayan Al ShareHadeel AssadJudith AbramsAbhinav DeolAsif AlaviDipenkumar ModiAndrew KinVoravit RatanatharathornJoseph UbertiLois AyashPublished in: Journal of oncology (2022)
This study of locally advanced/high-risk triple-negative breast cancer treated with adjuvant high-dose chemotherapy and autologous stem cell transplant reveals high overall survival rate. With the current improvement in treatment-related mortality, re-evaluating this approach in this subset of high-risk breast cancer in prospective randomized studies may be worthwhile.
Keyphrases
- high dose
- locally advanced
- stem cell transplantation
- rectal cancer
- neoadjuvant chemotherapy
- squamous cell carcinoma
- low dose
- stem cells
- phase ii study
- radiation therapy
- bone marrow
- cell therapy
- early stage
- open label
- double blind
- cardiovascular events
- risk factors
- phase iii
- randomized controlled trial
- coronary artery disease
- phase ii
- case control
- mesenchymal stem cells
- lymph node