Population pharmacokinetics of sildenafil in extremely premature infants.

Daniel GonzalezMatthew M LaughonP Brian SmithShufan GeNamasivayam Ambalavanan Andrew M AtzGregory M SokolChi D HornikDan StewartGratias MundakelBrenda B PoindexterRoger GaedigkMary MillsMichael Cohen-WolkowiezKaren MartzChristoph P Horniknull null

Published in: British journal of clinical pharmacology (2019)

We successfully characterized the PK of sildenafil and DMS in premature infants and applied the model to inform dosing for a follow-up, phase II study.

Keyphrases

phase ii study
pulmonary hypertension
pulmonary arterial hypertension
open label
locally advanced
placebo controlled
clinical trial
squamous cell carcinoma
randomized controlled trial
rectal cancer