Harnessing the Power of Stimuli-Responsive Nanoparticles as an Effective Therapeutic Drug Delivery System.
Mahak FatimaWaleed H AlmalkiTasneem KhanAmirhossein SahebkarPrashant KesharwaniPublished in: Advanced materials (Deerfield Beach, Fla.) (2024)
The quest for effective and reliable methods of delivering medications, with the aim of improving delivery of therapeutic agent to the intended location has presented a demanding yet captivating field in biomedical research. The concept of smart drug delivery systems is an evolving therapeutic approach, serving as a model for directing drugs to specific targets or sites. These systems have been developed to specifically target and regulate the administration of therapeutic substances in a diverse array of chronic conditions, including periodontitis, diabetes, cardiac diseases, inflammatory bowel diseases, rheumatoid arthritis, and different cancers. Nevertheless, numerous comprehensive clinical trials are still required to ascertain both the immediate and enduring impacts of such nanosystems on human subjects. This review delves into the benefits of different drug delivery vehicles, aiming to enhance comprehension of their applicability in addressing present medical requirements. Additionally, it touches upon the current applications of these stimuli-reactive nanosystems in biomedicine and outlines future development prospects. This article is protected by copyright. All rights reserved.
Keyphrases
- rheumatoid arthritis
- clinical trial
- drug delivery
- endothelial cells
- type diabetes
- current status
- healthcare
- cardiovascular disease
- cancer therapy
- randomized controlled trial
- high resolution
- heart failure
- left ventricular
- systemic lupus erythematosus
- drinking water
- interstitial lung disease
- high throughput
- systemic sclerosis
- phase ii
- single cell
- atrial fibrillation
- induced pluripotent stem cells
- disease activity
- idiopathic pulmonary fibrosis