Insight into Novel Treatment for Cognitive Dysfunctions across Disorders.

Thomas D PrevotGuanguan LiJames M CookEtienne Sibille

Published in: ACS chemical neuroscience (2019)

Cognitive dysfunctions, including impaired attention, learning, memory, and problem solving, occur in psychiatric diseases, such as depression, and are a hallmark of aging. Altered GABAergic signaling is similarly reported across these conditions, but therapeutic approaches are limited by pan-receptor activities of benzodiazepine-like ligands. α5-GABA-A receptor-preferring ligands uncover novel therapeutics for cognitive dysfunctions.

Keyphrases

working memory
depressive symptoms
small molecule
combination therapy
sleep quality
replacement therapy