James M Cook (James Cook)

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 35

Top Topics

Parkinson Disease

Temporal Lobe Epilepsy

Top Venues

ACS chemical neuroscience

Molecules (Basel, Switzerland)

Molecular pharmaceutics

This page only lists publications with an associated author ORCID identifier.

Publications

Dishary Sharmin, Branka Divović, Xingjie Ping, Rok Cerne, Jodi L Smith, Sepideh Rezvanian, Prithu Mondal, Michelle Jean Meyer, Molly E Kiley, Leggy A Arnold, Md Yeunus Mian, Kamel Prasad Pandey, Xiaoming Jin, Jelena R Mitrović, Djordje Djorović, Arnold Lippa, James M Cook, Lalit K Golani, Petra Scholze, Miroslav M Savić, Jeffrey M Witkin
New Imidazodiazepine Analogue, 5-(8-Bromo-6-(pyridin-2-yl)-4 H -benzo[ f ]imidazo[1,5- a ][1,4]diazepin-3-yl)oxazole, Provides a Simplified Synthetic Scheme, High Oral Plasma and Brain Exposures, and Produces Antiseizure Efficacy in Mice, and Antiepileptogenic Activity in Neural Networks in Brain Slices from a Patient with Mesial Temporal Lobe Epilepsy. ACS chemical neuroscience (2024)
Dishary Sharmin, Branka Divović, Xingjie Ping, Rok Cerne, Jodi L Smith, Sepideh Rezvanian, Prithu Mondal, Michelle Jean Meyer, Molly E Kiley, Leggy A Arnold, Md Yeunus Mian, Kamel Prasad Pandey, Xiaoming Jin, Jelena R Mitrović, Djordje Djorović, Arnold Lippa, James M Cook, Lalit K Golani, Petra Scholze, Miroslav M Savić, Jeffrey M Witkin
New Imidazodiazepine Analogue, 5-(8-Bromo-6-(pyridin-2-yl)-4 H -benzo[ f ]imidazo[1,5- a ][1,4]diazepin-3-yl)oxazole, Provides a Simplified Synthetic Scheme, High Oral Plasma and Brain Exposures, and Produces Antiseizure Efficacy in Mice, and Antiepileptogenic Activity in Neural Networks in Brain Slices from a Patient with Mesial Temporal Lobe Epilepsy. ACS chemical neuroscience (2024)
Dishary Sharmin, Branka Divović, Xingjie Ping, Rok Cerne, Jodi L Smith, Sepideh Rezvanian, Prithu Mondal, Michelle Jean Meyer, Molly E Kiley, Leggy A Arnold, Md Yeunus Mian, Kamel Prasad Pandey, Xiaoming Jin, Jelena R Mitrović, Djordje Djorović, Arnold Lippa, James M Cook, Lalit K Golani, Petra Scholze, Miroslav M Savić, Jeffrey M Witkin
New Imidazodiazepine Analogue, 5-(8-Bromo-6-(pyridin-2-yl)-4 H -benzo[ f ]imidazo[1,5- a ][1,4]diazepin-3-yl)oxazole, Provides a Simplified Synthetic Scheme, High Oral Plasma and Brain Exposures, and Produces Antiseizure Efficacy in Mice, and Antiepileptogenic Activity in Neural Networks in Brain Slices from a Patient with Mesial Temporal Lobe Epilepsy. ACS chemical neuroscience 15 (3) (2024)
Dishary Sharmin, Branka Divović, Xingjie Ping, Rok Cerne, Jodi L Smith, Sepideh Rezvanian, Prithu Mondal, Michelle Jean Meyer, Molly E Kiley, Leggy A Arnold, Md Yeunus Mian, Kamel Prasad Pandey, Xiaoming Jin, Jelena R Mitrović, Djordje Djorović, Arnold Lippa, James M Cook, Lalit K Golani, Petra Scholze, Miroslav M Savić, Jeffrey M Witkin
New Imidazodiazepine Analogue, 5-(8-Bromo-6-(pyridin-2-yl)-4 H -benzo[ f ]imidazo[1,5- a ][1,4]diazepin-3-yl)oxazole, Provides a Simplified Synthetic Scheme, High Oral Plasma and Brain Exposures, and Produces Antiseizure Efficacy in Mice, and Antiepileptogenic Activity in Neural Networks in Brain Slices from a Patient with Mesial Temporal Lobe Epilepsy. ACS chemical neuroscience 15 (3) (2024)
Dishary Sharmin, Branka Divović, Xingjie Ping, Rok Cerne, Jodi L Smith, Sepideh Rezvanian, Prithu Mondal, Michelle Jean Meyer, Molly E Kiley, Leggy A Arnold, Md Yeunus Mian, Kamel Prasad Pandey, Xiaoming Jin, Jelena R Mitrović, Djordje Djorović, Arnold Lippa, James M Cook, Lalit K Golani, Petra Scholze, Miroslav M Savić, Jeffrey M Witkin
New Imidazodiazepine Analogue, 5-(8-Bromo-6-(pyridin-2-yl)-4 H -benzo[ f ]imidazo[1,5- a ][1,4]diazepin-3-yl)oxazole, Provides a Simplified Synthetic Scheme, High Oral Plasma and Brain Exposures, and Produces Antiseizure Efficacy in Mice, and Antiepileptogenic Activity in Neural Networks in Brain Slices from a Patient with Mesial Temporal Lobe Epilepsy. ACS chemical neuroscience 15 (3) (2024)
Dishary Sharmin, Branka Divović, Xingjie Ping, Rok Cerne, Jodi L Smith, Sepideh Rezvanian, Prithu Mondal, Michelle Jean Meyer, Molly E Kiley, Leggy A Arnold, Md Yeunus Mian, Kamel Prasad Pandey, Xiaoming Jin, Jelena R Mitrović, Djordje Djorović, Arnold Lippa, James M Cook, Lalit K Golani, Petra Scholze, Miroslav M Savić, Jeffrey M Witkin
New Imidazodiazepine Analogue, 5-(8-Bromo-6-(pyridin-2-yl)-4 H -benzo[ f ]imidazo[1,5- a ][1,4]diazepin-3-yl)oxazole, Provides a Simplified Synthetic Scheme, High Oral Plasma and Brain Exposures, and Produces Antiseizure Efficacy in Mice, and Antiepileptogenic Activity in Neural Networks in Brain Slices from a Patient with Mesial Temporal Lobe Epilepsy. ACS chemical neuroscience (2024)
Barbara Kosmowska, Martyna Paleczna, Dominika Biała, Justyna Kadłuczka, Jadwiga Wardas, Jeffrey M Witkin, James M Cook, Dishary Sharmin, Monika Marcinkowska, Katarzyna Z Kuter
GABA-A Alpha 2/3 but Not Alpha 1 Receptor Subunit Ligand Inhibits Harmaline and Pimozide-Induced Tremor in Rats. Biomolecules 13 (2) (2023)
Dishary Sharmin, Md Yeunus Mian, Michael Marcotte, Thomas D Prevot, Etienne Sibille, Jeffrey M Witkin, James M Cook
Synthesis and Receptor Binding Studies of α5 GABA A R Selective Novel Imidazodiazepines Targeted for Psychiatric and Cognitive Disorders. Molecules (Basel, Switzerland) 28 (12) (2023)
Alexandra M McCoy, Thomas D Prevot, Dishary Sharmin, James M Cook, Etienne L Sibille, Daniel J Lodge
GL-II-73, a Positive Allosteric Modulator of α5GABA A Receptors, Reverses Dopamine System Dysfunction Associated with Pilocarpine-Induced Temporal Lobe Epilepsy. International journal of molecular sciences 24 (14) (2023)
Dishary Sharmin, Md Yeunus Mian, Michael Marcotte, Thomas D Prevot, Etienne Sibille, Jeffrey M Witkin, James M Cook
Synthesis and Receptor Binding Studies of α5 GABA A R Selective Novel Imidazodiazepines Targeted for Psychiatric and Cognitive Disorders. Molecules (Basel, Switzerland) 28 (12) (2023)
Barbara Kosmowska, Martyna Paleczna, Dominika Biała, Justyna Kadłuczka, Jadwiga Wardas, Jeffrey M Witkin, James M Cook, Dishary Sharmin, Monika Marcinkowska, Katarzyna Z Kuter
GABA-A Alpha 2/3 but Not Alpha 1 Receptor Subunit Ligand Inhibits Harmaline and Pimozide-Induced Tremor in Rats. Biomolecules 13 (2) (2023)
Nicole E Eassa, Stephanie M Perez, Angela M Boley, Hannah B Elam, Dishary Sharmin, James M Cook, Daniel J Lodge
α5-GABAA Receptor Modulation Reverses Behavioral and Neurophysiological Correlates of Psychosis in Rats with Ventral Hippocampal Alzheimer's Disease-like Pathology. International journal of molecular sciences 24 (14) (2023)
Barbara Kosmowska, Martyna Paleczna, Dominika Biała, Justyna Kadłuczka, Jadwiga Wardas, Jeffrey M Witkin, James M Cook, Dishary Sharmin, Monika Marcinkowska, Katarzyna Z Kuter
GABA-A Alpha 2/3 but Not Alpha 1 Receptor Subunit Ligand Inhibits Harmaline and Pimozide-Induced Tremor in Rats. Biomolecules 13 (2) (2023)
Barbara Kosmowska, Martyna Paleczna, Dominika Biała, Justyna Kadłuczka, Jadwiga Wardas, Jeffrey M Witkin, James M Cook, Dishary Sharmin, Monika Marcinkowska, Katarzyna Z Kuter
GABA-A Alpha 2/3 but Not Alpha 1 Receptor Subunit Ligand Inhibits Harmaline and Pimozide-Induced Tremor in Rats. Biomolecules 13 (2) (2023)
Dishary Sharmin, Md Yeunus Mian, Michael Marcotte, Thomas D Prevot, Etienne Sibille, Jeffrey M Witkin, James M Cook
Synthesis and Receptor Binding Studies of α5 GABA A R Selective Novel Imidazodiazepines Targeted for Psychiatric and Cognitive Disorders. Molecules (Basel, Switzerland) 28 (12) (2023)
Md Toufiqur Rahman, Veera Venkata Naga Phani Babu Tiruveedhula, Michael Rajesh Stephen, Sundari K Rallapalli, Kamel Prasad Pandey, James M Cook
Completion of the Total Synthesis of Several Bioactive Sarpagine/Macroline Alkaloids including the Important NF-κB Inhibitor N 4 -Methyltalpinine. Molecules (Basel, Switzerland) 27 (5) (2022)
Nicolas M Zahn, M S Rashid Roni, Gene T Yocum, Michelle J Meyer, Daniel A Webb, Md Yeunus Mian, James M Cook, Douglas C Stafford, Charles W Emala, Leggy A Arnold
Development of Inhaled GABA A Receptor Modulators to Improve Airway Function in Bronchoconstrictive Disorders. ACS pharmacology & translational science 5 (2) (2022)
Md Yeunus Mian, Branka Divović, Dishary Sharmin, Kamel Prasad Pandey, Lalit K Golani, V V N Phani Babu Tiruveedhula, Rok Cerne, Jodi L Smith, Xingjie Ping, Xiaoming Jin, Gregory H Imler, Jeffrey R Deschamps, Arnold Lippa, James M Cook, Miroslav M Savić, James Rowlett, Jeffrey M Witkin
Hydrochloride Salt of the GABAkine KRM-II-81. ACS omega 7 (31) (2022)
Kamal P Pandey, Md Toufiqur Rahman, James M Cook
Bisindole Alkaloids from the Alstonia Species: Recent Isolation, Bioactivity, Biosynthesis, and Synthesis. Molecules (Basel, Switzerland) 26 (11) (2021)
Roberto Cadeddu, Daniel E Knutson, Laura J Mosher, Stefanos Loizou, Karen Odeh, Janet L Fisher, James M Cook, Marco Bortolato
The α6 GABAA Receptor Positive Allosteric Modulator DK-I-56-1 Reduces Tic-Related Behaviors in Mouse Models of Tourette Syndrome. Biomolecules 11 (2) (2021)
Jelena R Mitrović, Branka Divović-Matović, Daniel E Knutson, Jelena B Đoković, Aleksandar Kremenović, Vladimir D Dobričić, Danijela V Randjelović, Ivana Pantelić, James M Cook, Miroslav M Savić, Snežana D Savić
Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach. Pharmaceutics 13 (8) (2021)
Amanda N Nieman, Guanguan Li, Nicolas M Zahn, Md Yeunus Mian, Brandon N Mikulsky, Dylan A Hoffman, Taylor M Wilcox, Alexander S Kehoe, Ian W Luecke, Michael M Poe, David Alvarez-Carbonell, James M Cook, Douglas C Stafford, Leggy A Arnold
Targeting Nitric Oxide Production in Microglia with Novel Imidazodiazepines for Nonsedative Pain Treatment. ACS chemical neuroscience 11 (13) (2020)
Guanguan Li, Amanda N Nieman, Md Yeunus Mian, Nicolas M Zahn, Brandon N Mikulsky, Michael M Poe, Kashi R Methuku, Yongfeng Liu, James M Cook, Douglas C Stafford, Leggy A Arnold
A Structure-Activity Relationship Comparison of Imidazodiazepines Binding at Kappa, Mu, and Delta Opioid Receptors and the GABAA Receptor. Molecules (Basel, Switzerland) 25 (17) (2020)
Daniel E Knutson, Jodi L Smith, Xingjie Ping, Xiao-Ming Jin, Lalit K Golani, Guanguan Li, Veera Venkata Naga Phani Babu Tiruveedhula, Farjana Rashid, Md Yeunus Mian, Rajwana Jahan, Dishary Sharmin, Rok Cerne, James M Cook, Jeffrey M Witkin
Imidazodiazepine Anticonvulsant, KRM-II-81, Produces Novel, Non-diazepam-like Antiseizure Effects. ACS chemical neuroscience 11 (17) (2020)
M S Rashid Roni, Guanguan Li, Brandon N Mikulsky, Daniel E Knutson, Md Yeunus Mian, Nicolas M Zahn, James M Cook, Douglas C Stafford, Leggy A Arnold
The Effects of pH on the Structure and Bioavailability of Imidazobenzodiazepine-3-Carboxylate MIDD0301. Molecular pharmaceutics 17 (4) (2020)
Thomas D Prevot, Guanguan Li, James M Cook, Etienne Sibille
Insight into Novel Treatment for Cognitive Dysfunctions across Disorders. ACS chemical neuroscience 10 (5) (2019)
Gloria S Forkuo, Amanda N Nieman, Revathi Kodali, Nicolas M Zahn, Guanguan Li, M S Rashid Roni, Michael Rajesh Stephen, Ted W Harris, Rajwana Jahan, Margaret L Guthrie, Olivia B Yu, Janet L Fisher, Gene T Yocum, Charles W Emala, Douglas A Steeber, Douglas C Stafford, James M Cook, Leggy A Arnold
Correction to "A Novel Orally Available Asthma Drug Candidate That Reduces Smooth Muscle Constriction and Inflammation by Targeting GABAA Receptors in the Lung". Molecular pharmaceutics 16 (11) (2019)
Md Toufiqur Rahman, Jeffrey R Deschamps, Gregory H Imler, James M Cook
Total Synthesis of Sarpagine-Related Bioactive Indole Alkaloids. Chemistry (Weinheim an der Bergstrasse, Germany) 24 (10) (2018)
Lih-Chu Chiou, Hsin-Jung Lee, Margot Ernst, Wei-Jan Huang, Jui-Feng Chou, Hon-Lie Chen, Akihiro Mouri, Liang-Chieh Chen, Marco Treven, Takayoshi Mamiya, Pi-Chuan Fan, Daniel E Knutson, Chris Witzigmann, James M Cook, Werner Sieghart, Toshitaka Nabeshima
Cerebellar α6 -subunit-containing GABAA receptors: a novel therapeutic target for disrupted prepulse inhibition in neuropsychiatric disorders. British journal of pharmacology 175 (12) (2018)
Gloria S Forkuo, Amanda N Nieman, Revathi Kodali, Nicolas M Zahn, Guanguan Li, M S Rashid Roni, Michael Rajesh Stephen, Ted W Harris, Rajwana Jahan, Margaret L Guthrie, Olivia B Yu, Janet L Fisher, Gene T Yocum, Charles W Emala, Douglas A Steeber, Douglas C Stafford, James M Cook, Leggy A Arnold
A Novel Orally Available Asthma Drug Candidate That Reduces Smooth Muscle Constriction and Inflammation by Targeting GABAA Receptors in the Lung. Molecular pharmaceutics 15 (5) (2018)
Alshaimaa A Elgarf, David C B Siebert, Friederike Steudle, Angelika Draxler, Guanguan Li, Shengming Huang, James M Cook, Margot Ernst, Petra Scholze
Different Benzodiazepines Bind with Distinct Binding Modes to GABAA Receptors. ACS chemical biology 13 (8) (2018)
Daniel E Knutson, Revathi Kodali, Branka Divović, Marco Treven, Michael Rajesh Stephen, Nicolas M Zahn, Vladimir Dobričić, Alec T Huber, Matheus A Meirelles, Ranjit S Verma, Laurin Wimmer, Christopher Witzigmann, Leggy A Arnold, Lih-Chu Chiou, Margot Ernst, Marko D Mihovilovic, Miroslav M Savić, Werner Sieghart, James M Cook
Design and Synthesis of Novel Deuterated Ligands Functionally Selective for the γ-Aminobutyric Acid Type A Receptor (GABAAR) α6 Subtype with Improved Metabolic Stability and Enhanced Bioavailability. Journal of medicinal chemistry 61 (6) (2018)
Michael Rajesh Stephen, Md Toufiqur Rahman, Veera Venkata Naga Phani Babu Tiruveedhula, German O Fonseca, Jeffrey R Deschamps, James M Cook
Concise Total Synthesis of (-)-Affinisine Oxindole, (+)-Isoalstonisine, (+)-Alstofoline, (-)-Macrogentine, (+)-Na -Demethylalstonisine, (-)-Alstonoxine A, and (+)-Alstonisine. Chemistry (Weinheim an der Bergstrasse, Germany) 23 (62) (2017)
Gloria S Forkuo, Amanda N Nieman, Nina Y Yuan, Revathi Kodali, Olivia B Yu, Nicolas M Zahn, Rajwana Jahan, Guanguan Li, Michael Rajesh Stephen, Margaret L Guthrie, Michael M Poe, Benjamin D Hartzler, Ted W Harris, Gene T Yocum, Charles W Emala, Douglas A Steeber, Douglas C Stafford, James M Cook, Leggy A Arnold
Alleviation of Multiple Asthmatic Pathologic Features with Orally Available and Subtype Selective GABAA Receptor Modulators. Molecular pharmaceutics 14 (6) (2017)
Lakeisha A Lewter, Janet L Fisher, Justin N Siemian, Kashi Reddy Methuku, Michael M Poe, James M Cook, Jun-Xu Li
Antinociceptive Effects of a Novel α2/α3-Subtype Selective GABAA Receptor Positive Allosteric Modulator. ACS chemical neuroscience 8 (6) (2017)