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Preparation and Evaluation of a Self-Nanoemulsifying Drug Delivery System Loaded with Heparin Phospholipid Complex.

Xiao-Lei QiuZi-Rui FanYang-Yang LiuDing-Fu WangShi-Xin WangChun-Xia Li
Published in: International journal of molecular sciences (2021)
A self-nanoemulsifying drug delivery system (SNEDDS) was developed to enhance the absorption of heparin after oral administration, in which heparin was compounded with phospholipids to achieve better fat solubility in the form of heparin-phospholipid (HEP-Pc) complex. HEP-Pc complex was prepared using the solvent evaporation method, which increased the solubility of heparin in n-octanol. The successful preparation of HEP-Pc complex was confirmed by differential scanning calorimetry (DSC), Fourier-transform infrared (FT-IR) spectroscopy, NMR, and SEM. A heparin lipid microemulsion (HEP-LM) was prepared by high-pressure homogenization and characterized. HEP-LM can enhance the absorption of heparin after oral administration, significantly prolong activated partial thromboplastin time (APTT) and thrombin time (TT) in mice, and reduce fibrinogen (FIB) content. All these outcomes indicate that HEP-LM has great potential as an oral heparin formulation.
Keyphrases
  • venous thromboembolism
  • growth factor
  • fatty acid
  • high resolution
  • drug delivery
  • magnetic resonance
  • risk assessment
  • metabolic syndrome
  • skeletal muscle
  • single molecule
  • ionic liquid
  • glycemic control