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Characterisation of patients with severe asthma in the UK Severe Asthma Registry in the biologic era.

David J JacksonJohn BusbyPaul E PfefferAndrew Menzies-GowThomas BrownRobin GoreMartin DohertyAdel Hasan MansurSimon MessageRobert NivenMitesh PatelLiam G Heaneynull null
Published in: Thorax (2020)
The UKSAR describes the characteristics of a large cohort of asthmatics referred to UK specialist severe asthma services. It offers the prospect of providing novel insights across a range of research areas and highlights substantial unmet need with poor asthma control, impaired lung function and high exacerbation rates. T2-high phenotypes predominate with significant differences apparent from T2-low patients. However, T2-low patients frequently have prior blood eosinophilia consistent with possible excessive corticosteroid exposure.
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