Characterisation of patients with severe asthma in the UK Severe Asthma Registry in the biologic era.
David J JacksonJohn BusbyPaul E PfefferAndrew Menzies-GowThomas BrownRobin GoreMartin DohertyAdel Hasan MansurSimon MessageRobert NivenMitesh PatelLiam G Heaneynull nullPublished in: Thorax (2020)
The UKSAR describes the characteristics of a large cohort of asthmatics referred to UK specialist severe asthma services. It offers the prospect of providing novel insights across a range of research areas and highlights substantial unmet need with poor asthma control, impaired lung function and high exacerbation rates. T2-high phenotypes predominate with significant differences apparent from T2-low patients. However, T2-low patients frequently have prior blood eosinophilia consistent with possible excessive corticosteroid exposure.
Keyphrases
- lung function
- end stage renal disease
- chronic obstructive pulmonary disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- healthcare
- peritoneal dialysis
- prognostic factors
- rheumatoid arthritis
- cystic fibrosis
- palliative care
- air pollution
- mental health
- magnetic resonance imaging
- cross sectional
- physical activity
- body mass index
- magnetic resonance
- mechanical ventilation