Histone demethylase KDM5D represses the proliferation, migration and invasion of hepatocellular carcinoma through the E2F1/TNNC1 axis.

Lili LiGenbao ZhuChen GongMengxue HuKemeng TanLa JiangYafen LiXiaohong ZhuPeng XieXilan ChenXianfen Yang

Published in: Antioxidants & redox signaling (2024)

KDM5D inhibits E2F1 expression by suppressing H3K4me3 modification in the E2F1 promoter region, which in turn suppresses the binding of E2F1 to the TNNC1 promoter region, thus leading to the inhibition of HCC development.

Keyphrases

dna methylation
signaling pathway
transcription factor
gene expression
poor prognosis
binding protein
fluorescent probe
living cells
sensitive detection
long non coding rna