Targeting Replication Stress and Chemotherapy Resistance with a Combination of Sacituzumab Govitecan and Berzosertib: A Phase I Clinical Trial.

Melissa L Abel Nobuyuki Takahashi Cody J Peer Christophe E Redon Samantha Nichols Rasa Vilimas Min-Jung Lee Min-Jung Lee Meenakshi Shelat Robbie Kattappuram Linda Sciuto Danielle Pinkiert Chante Graham Donna Butcher Baktiar O Karim Ajit Kumar Sharma Justin Malin Rajesh Kumar Christopher W Schultz Shubhank Goyal Jaydira Del Rivero Manan Krishnamurthy Deep Upadhyay Brett A Schroeder Tristan M Sissung Manoj Tyagi Jung Kim Yves Pommier Mirit I Aladjem Mark Raffeld William Douglas Figg Jane Trepel Liqiang Xi Parth Desai Anish Thomas

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

ADC-based delivery of cytotoxic payloads represents a new paradigm to increase efficacy of DDR inhibitors.

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