Yves Pommier

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 50

Top Topics

Diffusion Weighted

Circulating Tumor

Top Venues

Cancer research communications

Clinical cancer research : an official journal of the American Association for Cancer Research

Nature communications

Molecular cancer therapeutics

This page only lists publications with an associated author ORCID identifier.

Publications

Makito Mizunuma, Christophe E Redon, Liton Kumar Saha, Andy D Tran, Anjali Dhall, Robin Sebastian, Daiki Taniyama, Michael J Kruhlak, William C Reinhold, Naoko Takebe, Yves Pommier
Acetalax (Oxyphenisatin Acetate, NSC 59687) and Bisacodyl Cause Oncosis in Triple-Negative Breast Cancer Cell Lines by Poisoning the Ion Exchange Membrane Protein TRPM4. Cancer research communications 4 (8) (2024)
Christopher W Schultz, Yang Zhang, Rajaa El Meskini, Astrid Zimmermann, Haiqing Fu, Yasuhisa Murai, Darawalee Wangsa, Suresh Kumar, Nobuyuki Takahashi, Devon A Atkinson, Liton Kumar Saha, Chien-Fei Lee, Brian Elenbaas, Parth Desai, Robin Sebastian, Ajit Kumar Sharma, Melissa Abel, Brett A Schroeder, Manan Krishnamurthy, Laurel L Bassel, Rajesh Kumar, Nitin Roper, Mirit I Aladjem, Frank T Zenke, Zoe Weaver Ohler, Yves Pommier, Anish Thomas
Author Correction: ATR inhibition augments the efficacy of lurbinectedin in small-cell lung cancer. EMBO molecular medicine (2024)
Makito Mizunuma, Christophe E Redon, Liton Kumar Saha, Andy D Tran, Anjali Dhall, Robin Sebastian, Daiki Taniyama, Michael J Kruhlak, William C Reinhold, Naoko Takebe, Yves Pommier
Acetalax (Oxyphenisatin Acetate, NSC 59687) and Bisacodyl Cause Oncosis in Triple-Negative Breast Cancer Cell Lines by Poisoning the Ion Exchange Membrane Protein TRPM4. Cancer research communications 4 (8) (2024)
Makito Mizunuma, Christophe E Redon, Liton Kumar Saha, Andy D Tran, Anjali Dhall, Robin Sebastian, Daiki Taniyama, Michael J Kruhlak, William C Reinhold, Naoko Takebe, Yves Pommier
Acetalax (Oxyphenisatin Acetate, NSC 59687) and Bisacodyl Cause Oncosis in Triple-Negative Breast Cancer Cell Lines by Poisoning the Ion Exchange Membrane Protein TRPM4. Cancer research communications 4 (8) (2024)
Makito Mizunuma, Christophe E Redon, Liton Kumar Saha, Andy D Tran, Anjali Dhall, Robin Sebastian, Daiki Taniyama, Michael J Kruhlak, William C Reinhold, Naoko Takebe, Yves Pommier
Acetalax (Oxyphenisatin acetate, NSC 59687) and bisacodyl Cause Oncosis in Triple Negative Breast Cancer Cell lines by Poisoning Ion Exchange Membrane Protein TRPM4. Cancer research communications (2024)
Yashuhiro Arakawa, Ukhyun Jo, Suresh Kumar, Nai-Yun Sun, Fathi Elloumi, Anish Thomas, Nitin Roper, Diana Grace Varghese, Naoko Takebe, Xiaohu Zhang, Michele Ceribelli, David O Holland, Eric Beck, Zina Itkin, Crystal McKnight, Kelli M Wilson, Jameson Travers, Carleen Klump-Thomas, Craig J Thomas, Chuong D Hoang, Jonathan M Hernandez, Jaydira Del Rivero, Yves Pommier
Activity of the ubiquitin-activating enzyme inhibitor TAK-243 in adrenocortical carcinoma (ACC) cell lines, patient-derived organoids (PDOs) and murine xenografts. Cancer research communications (2024)
Yashuhiro Arakawa, Ukhyun Jo, Suresh Kumar, Nai-Yun Sun, Fathi Elloumi, Anish Thomas, Nitin Roper, Diana Grace Varghese, Naoko Takebe, Xiaohu Zhang, Michele Ceribelli, David O Holland, Eric Beck, Zina Itkin, Crystal McKnight, Kelli M Wilson, Jameson Travers, Carleen Klump-Thomas, Craig J Thomas, Chuong D Hoang, Jonathan M Hernandez, Jaydira Del Rivero, Yves Pommier
Activity of the ubiquitin-activating enzyme inhibitor TAK-243 in adrenocortical carcinoma (ACC) cell lines, patient-derived organoids (PDOs) and murine xenografts. Cancer research communications (2024)
Yashuhiro Arakawa, Fathi Elloumi, Sudhir Varma, Prashant Khandagale, Ukhyun Jo, Suresh Kumar, Nitin Roper, William C Reinhold, Robert W Robey, Naoko Takebe, Michael M Gottesman, Craig J Thomas, Valentina Boeva, Alfredo Berruti, Andrea Abate, Mariangela Tamburello, Sandra Sigala, Constanze Hantel, Isabel Weigand, Margaret E Wierman, Katja Kiseljak-Vassiliades, Jaydira Del Rivero, Yves Pommier
A Database Tool Integrating Genomic and Pharmacologic Data from Adrenocortical Carcinoma (ACC) Cell Lines, PDX, and Patient Samples. Cancer research communications (2024)
Yashuhiro Arakawa, Ukhyun Jo, Suresh Kumar, Nai-Yun Sun, Fathi Elloumi, Anish Thomas, Nitin Roper, Diana Grace Varghese, Naoko Takebe, Xiaohu Zhang, Michele Ceribelli, David O Holland, Eric Beck, Zina Itkin, Crystal McKnight, Kelli M Wilson, Jameson Travers, Carleen Klump-Thomas, Craig J Thomas, Chuong D Hoang, Jonathan M Hernandez, Jaydira Del Rivero, Yves Pommier
Activity of the Ubiquitin-activating Enzyme Inhibitor TAK-243 in Adrenocortical Carcinoma Cell Lines, Patient-derived Organoids, and Murine Xenografts. Cancer research communications 4 (3) (2024)
Ukhyun Jo, Yashuhiro Arakawa, Astrid Zimmermann, Daiki Taniyama, Makito Mizunuma, Lisa M Miller Jenkins, Tapan Maity, Suresh Kumar, Frank T Zenke, Naoko Takebe, Yves Pommier
The novel ATR inhibitor M1774 induces replication protein overexpression and broad synergy with DNA-targeted anticancer drugs. Molecular cancer therapeutics (2024)
Makito Mizunuma, Christophe E Redon, Liton Kumar Saha, Andy D Tran, Anjali Dhall, Robin Sebastian, Daiki Taniyama, Michael J Kruhlak, William C Reinhold, Naoko Takebe, Yves Pommier
Acetalax (Oxyphenisatin Acetate, NSC 59687) and Bisacodyl Cause Oncosis in Triple-Negative Breast Cancer Cell Lines by Poisoning the Ion Exchange Membrane Protein TRPM4. Cancer research communications 4 (8) (2024)
Ukhyun Jo, Yashuhiro Arakawa, Astrid Zimmermann, Daiki Taniyama, Makito Mizunuma, Lisa M Miller Jenkins, Tapan Maity, Suresh Kumar, Frank T Zenke, Naoko Takebe, Yves Pommier
The Novel ATR Inhibitor M1774 Induces Replication Protein Overexpression and Broad Synergy with DNA-targeted Anticancer Drugs. Molecular cancer therapeutics 23 (7) (2024)
Yashuhiro Arakawa, Ukhyun Jo, Suresh Kumar, Nai-Yun Sun, Fathi Elloumi, Anish Thomas, Nitin Roper, Diana Grace Varghese, Naoko Takebe, Xiaohu Zhang, Michele Ceribelli, David O Holland, Eric Beck, Zina Itkin, Crystal McKnight, Kelli M Wilson, Jameson Travers, Carleen Klump-Thomas, Craig J Thomas, Chuong D Hoang, Jonathan M Hernandez, Jaydira Del Rivero, Yves Pommier
Activity of the ubiquitin-activating enzyme inhibitor TAK-243 in adrenocortical carcinoma (ACC) cell lines, patient-derived organoids (PDOs) and murine xenografts. Cancer research communications (2024)
Liton Kumar Saha, Sourav Saha, Xi Yang, Shar-Yin Naomi Huang, Yilun Sun, Ukhyun Jo, Yves Pommier
Replication-associated formation and repair of human topoisomerase IIIα cleavage complexes. Nature communications 14 (1) (2023)
Melissa L Abel, Nobuyuki Takahashi, Cody J Peer, Christophe E Redon, Samantha Nichols, Rasa Vilimas, Min-Jung Lee, Min-Jung Lee, Meenakshi Shelat, Robbie Kattappuram, Linda Sciuto, Danielle Pinkiert, Chante Graham, Donna Butcher, Baktiar O Karim, Ajit Kumar Sharma, Justin Malin, Rajesh Kumar, Christopher W Schultz, Shubhank Goyal, Jaydira Del Rivero, Manan Krishnamurthy, Deep Upadhyay, Brett A Schroeder, Tristan M Sissung, Manoj Tyagi, Jung Kim, Yves Pommier, Mirit I Aladjem, Mark Raffeld, William Douglas Figg, Jane Trepel, Liqiang Xi, Parth Desai, Anish Thomas
Targeting Replication Stress and Chemotherapy Resistance with a Combination of Sacituzumab Govitecan and Berzosertib: A Phase I Clinical Trial. Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Melissa L Abel, Nobuyuki Takahashi, Cody J Peer, Christophe E Redon, Samantha Nichols, Rasa Vilimas, Min-Jung Lee, Min-Jung Lee, Meenakshi Shelat, Robbie Kattappuram, Linda Sciuto, Danielle Pinkiert, Chante Graham, Donna Butcher, Baktiar O Karim, Ajit Kumar Sharma, Justin Malin, Rajesh Kumar, Christopher W Schultz, Shubhank Goyal, Jaydira Del Rivero, Manan Krishnamurthy, Deep Upadhyay, Brett A Schroeder, Tristan M Sissung, Manoj Tyagi, Jung Kim, Yves Pommier, Mirit I Aladjem, Mark Raffeld, William Douglas Figg, Jane Trepel, Liqiang Xi, Parth Desai, Anish Thomas
Targeting Replication Stress and Chemotherapy Resistance with a Combination of Sacituzumab Govitecan and Berzosertib: A Phase I Clinical Trial. Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Yilun Sun, Jiji Chen, Yves Pommier
Real-time imaging of drug-induced trapping of cellular topoisomerases and poly(ADP-ribose) polymerase 1 at the single-molecule level. Nucleic acids research (2023)
Yves Pommier, Anish Thomas
New Life of Topoisomerase I Inhibitors as Antibody-Drug Conjugate Warheads. Clinical cancer research : an official journal of the American Association for Cancer Research 29 (6) (2023)
William C Reinhold, Kelli M Wilson, Fathi Elloumi, Katie Rebecca Bradwell, Michele Ceribelli, Sudhir Varma, Yanghsin Wang, Damien Y Duveau, Nikhil Menon, Jane Trepel, Xiaohu Zhang, Carleen Klump-Thomas, Samuel Michael, Paul Shinn, Augustin Luna, Craig J Thomas, Yves Pommier
CellMinerCDB: NCATS is a Web-Based Portal Integrating Public Cancer Cell Line Databases for Pharmacogenomic Explorations. Cancer research (2023)
Yves Pommier, Anish Thomas
New Life of Topoisomerase I Inhibitors as Antibody Drug Conjugate Warheads. Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Junko Murai, Michele Ceribelli, Haiqing Fu, Christophe E Redon, Ukhyun Jo, Yasuhisa Murai, Mirit I Aladjem, Craig J Thomas, Yves Pommier
Schlafen 11 (SLFN11) kills cancer cells undergoing unscheduled re-replication. Molecular cancer therapeutics (2023)
Yves Pommier, Anish Thomas
New Life of Topoisomerase I Inhibitors as Antibody-Drug Conjugate Warheads. Clinical cancer research : an official journal of the American Association for Cancer Research 29 (6) (2023)
Eka-Putra Gusti-Ngurah-Putu, Laurent Cattiaux, Thomas Lavergne, Yves Pommier, Sophie Bombard, Anton Granzhan
Unprecedented reactivity of polyamines with aldehydic DNA modifications: structural determinants of reactivity, characterization and enzymatic stability of adducts. Nucleic acids research (2023)
Huimin Zhang, Yun Xiong, Yilun Sun, Jeong-Min Park, Dan Su, Xu Feng, Sarah Keast, Mengfan Tang, Min Huang, Chao Wang, Mrinal Srivastava, Chang Yang, Dandan Zhu, Zhen Chen, Siting Li, Ling Yin, Yves Pommier, Junjie Chen
RAD54L2-mediated DNA damage avoidance pathway specifically preserves genome integrity in response to topoisomerase 2 poisons. Science advances 9 (49) (2023)
Lorinc Sandor Pongor, Christopher W Schultz, Lorenzo Rinaldi, Darawalee Wangsa, Christophe E Redon, Nobuyuki Takahashi, Gavriel Fialkoff, Parth Desai, Yang Zhang, Sandra Sczerba Burkett, Nadav Hermoni, Noa Vilk, Jenia Gutin, Gergely Rona, Yongmei Zhao, Samantha Nichols, Rasa Vilimas, Linda Sciuto, Chante Graham, Juan Manuel Caravaca, Sevilay Turan, Tsai-Wei Shen, Vinodh N Rajapakse, Rajesh Kumar, Deep Upadhyay, Suresh Kumar, Yoo-Sun Kim, Nitin Roper, Bao Tran, Stephen M Hewitt, David E Kleiner, Mirit I Aladjem, Nir Friedman, Gordon L Hager, Yves Pommier, Thomas Ried, Anish Thomas
Extrachromosomal DNA Amplification Contributes to Small Cell Lung Cancer Heterogeneity and is Associated with Worse Outcomes. Cancer discovery (2023)
Wenjie Wang, Sourav Saha, Xi Yang, Yves Pommier, Shar-Yin N Huang
Identification and characterization of topoisomerase III beta poisons. Proceedings of the National Academy of Sciences of the United States of America 120 (34) (2023)
Sourav Saha, Shar-Yin Naomi Huang, Xi Yang, Liton Kumar Saha, Yilun Sun, Prashant Khandagale, Lisa M Miller Jenkins, Yves Pommier
The TDRD3-USP9X complex and MIB1 regulate TOP3B homeostasis and prevent deleterious TOP3B cleavage complexes. Nature communications 14 (1) (2023)
Junko Murai, Yves Pommier
BRCAness, Homologous Recombination Deficiencies, and Synthetic Lethality. Cancer research 83 (8) (2023)
Yilun Sun, Simone A Baechler, Xiaohu Zhang, Suresh Kumar, Valentina M Factor, Yasuhiro Arakawa, Cindy H Chau, Kanako Okamoto, Anup Parikh, Robert L Walker, Yijun P Su, Jiji Chen, Tabitha Ting, Shar-Yin N Huang, Erin Beck, Zina Itkin, Crystal McKnight, Changqing Xie, Nitin Roper, Deepak Nijhawan, William Douglas Figg, Paul S Meltzer, James C Yang, Craig J Thomas, Yves Pommier
Targeting neddylation sensitizes colorectal cancer to topoisomerase I inhibitors by inactivating the DCAF13-CRL4 ubiquitin ligase complex. Nature communications 14 (1) (2023)
Yves Pommier, Anish Thomas
New Life of Topoisomerase I Inhibitors as Antibody-Drug Conjugate Warheads. Clinical cancer research : an official journal of the American Association for Cancer Research 29 (6) (2023)
Christopher W Schultz, Yang Zhang, Rajaa El Meskini, Astrid Zimmermann, Haiqing Fu, Yasuhisa Murai, Darawalee Wangsa, Suresh Kumar, Nobuyuki Takahashi, Devon A Atkinson, Liton Kumar Saha, Chien-Fei Lee, Brian Elenbaas, Parth Desai, Robin Sebastian, Ajit Kumar Sharma, Melissa Abel, Brett A Schroeder, Manan Krishnamurthy, Rajesh Kumar, Nitin Roper, Mirit I Aladjem, Frank T Zenke, Zoe Weaver Ohler, Yves Pommier, Anish Thomas
ATR inhibition augments the efficacy of lurbinectedin in small-cell lung cancer. EMBO molecular medicine (2023)
Yves Pommier, Anish Thomas
New Life of Topoisomerase I Inhibitors as Antibody-Drug Conjugate Warheads. Clinical cancer research : an official journal of the American Association for Cancer Research 29 (6) (2023)
Sourav Saha, Yves Pommier
R-loops, type I topoisomerases and cancer. NAR cancer 5 (1) (2023)
Shuqi Chen, Daniel L Priebbenow, Julie Somkhit, Carmen V Scullino, Keli Agama, Yves Pommier, Annaliese S Dillon
Alkyne Activation in the Diversity Oriented Synthesis of sp 2 -Rich Scaffolds: A Biased Library Approach for Targeting Polynucleotides (DNA/RNA). Chemistry (Weinheim an der Bergstrasse, Germany) (2022)
Yilun Sun, Yang Zhang, Christopher W Schultz, Yves Pommier, Anish Thomas
CDK7 Inhibition Synergizes with Topoisomerase I Inhibition in Small Cell Lung Cancer Cells by Inducing Ubiquitin-Mediated Proteolysis of RNA Polymerase II. Molecular cancer therapeutics 21 (9) (2022)
Xi Yang, Sourav Saha, Wei Yang, Keir C Neuman, Yves Pommier
Structural and biochemical basis for DNA and RNA catalysis by human Topoisomerase 3β. Nature communications 13 (1) (2022)
Tomio S Takahashi, Danièle Gadelle, Keli Agama, Evgeny Kiselev, Hongliang Zhang, Emilie Yab, Stephanie Petrella, Patrick Forterre, Yves Pommier, Claudine Mayer
Topoisomerase I (TOP1) dynamics: conformational transition from open to closed states. Nature communications 13 (1) (2022)
Jessica Marinello, Andrea Arleo, Marco Russo, Maria Delcuratolo, Francesca Ciccarelli, Yves Pommier, Giovanni Capranico
Topoisomerase I poison-triggered immune gene activation is markedly reduced in human small-cell lung cancers by impairment of the cGAS/STING pathway. British journal of cancer 127 (7) (2022)
Anish Thomas, Shaun D Fontaine, Morgan E Diolati, Parth Desai, Rajesh Kumar, Nobuyuki Takahashi, Linda Sciuto, Samantha Nichols, Alan Ashworth, Felix Y Feng, Gary W Ashley, Minh Nguyen, Yves Pommier, Daniel V Santi
PLX038: A Long-Acting Topoisomerase I Inhibitor With Robust Antitumor Activity in ATM-Deficient Tumors and Potent Synergy With PARP Inhibitors. Molecular cancer therapeutics 21 (11) (2022)
Ukhyun Jo, Yasuhisa Murai, Keli K Agama, Yilun Sun, Liton Kumar Saha, Xi Yang, Yasuhiro Arakawa, Sophia Gayle, Kelli Jones, Vishwas Paralkar, Ranjini K Sundaram, Jinny Van Doorn, Juan C Vasquez, Ranjit S Bindra, Woo Suk Choi, Yves Pommier
TOP1-DNA Trapping by Exatecan and Combination Therapy with ATR Inhibitor. Molecular cancer therapeutics 21 (7) (2022)
Yves Pommier, André Nussenzweig, Shunichi Takeda, Caroline A Austin
Human topoisomerases and their roles in genome stability and organization. Nature reviews. Molecular cell biology 23 (6) (2022)
Camille Tlemsani, Nobuyuki Takahashi, Lorinc Sandor Pongor, Vinodh N Rajapakse, Manoj Tyagi, Xinyu Wen, Grace-Ann Fasaye, Keith T Schmidt, Parth Desai, Chul Kim, Arun Rajan, Shannon Swift, Linda Sciuto, Rasa Vilimas, Santhana Webb, Samantha Nichols, William Douglas Figg, Yves Pommier, Kathleen Calzone, Seth M Steinberg, Jun S Wei, Udayan Guha, Clesson E Turner, Javed Khan, Anish Thomas
Whole-exome sequencing reveals germline-mutated small cell lung cancer subtype with favorable response to DNA repair-targeted therapies. Science translational medicine 13 (578) (2021)
Ukhyun Jo, Yasuhisa Murai, Naoko Takebe, Anish Thomas, Yves Pommier
Precision Oncology with Drugs Targeting the Replication Stress, ATR, and Schlafen 11. Cancers 13 (18) (2021)
Yilun Sun, Jiji Chen, Shar-Yin N Huang, Yijun P Su, Wenjie Wang, Keli Agama, Sourav Saha, Lisa M Jenkins, John M Pascal, Yves Pommier
PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation. Nature communications 12 (1) (2021)
De-Xuan Hu, Wen-Lin Tang, Yu Zhang, Hao Yang, Wenjie Wang, Keli Agama, Yves Pommier, Lin-Kun An
Synthesis of Methoxy-, Methylenedioxy-, Hydroxy-, and Halo-Substituted Benzophenanthridinone Derivatives as DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors and Their Biological Activity for Drug-Resistant Cancer. Journal of medicinal chemistry 64 (11) (2021)
Florence Coussy, Rania El-Botty, Sophie Château-Joubert, Ahmed Dahmani, Elodie Montaudon, Sophie Leboucher, Ludivine Morisset, Pierre Painsec, Laura Sourd, Léa Huguet, Fariba Nemati, Jean-Luc Servely, Thibaut Larcher, Sophie Vacher, Adrien Briaux, Cécile Reyes, Philippe La Rosa, Georges Lucotte, Tatiana Popova, Pierre Foidart, Nor Eddine Sounni, Agnès Noel, Didier Decaudin, Laëtitia Furhmann, Anne Salomon, Fabien Reyal, Christopher R Mueller, Petra Ter Brugge, Jos Jonkers, Marie-France Poupon, Marc-Henri Stern, Ivan Bièche, Yves Pommier, Elisabetta Marangoni
BRCAness, SLFN11, and RB1 loss predict response to topoisomerase I inhibitors in triple-negative breast cancers. Science translational medicine 12 (531) (2021)
Shar-Yin N Huang, Stephanie A Michaels, Brianna B Mitchell, Nadim Majdalani, Arnaud Vanden Broeck, Andres Canela, Yuk-Ching Tse-Dinh, Valérie Lamour, Yves Pommier
Exonuclease VII repairs quinolone-induced damage by resolving DNA gyrase cleavage complexes. Science advances 7 (10) (2021)
Yilun Sun, Lisa M Miller Jenkins, Yijun P Su, Karin C Nitiss, John L Nitiss, Yves Pommier
A conserved SUMO pathway repairs topoisomerase DNA-protein cross-links by engaging ubiquitin-mediated proteasomal degradation. Science advances 6 (46) (2020)
Shar-Yin N Huang, Ilaria Dalla Rosa, Stephanie A Michaels, David V Tulumello, Keli Agama, Salim Khiati, Sae Rin Jean, Simone A Baechler, Valentina M Factor, Sudhir Varma, Junko Murai, Lisa M Miller Jenkins, Shana O Kelley, Yves Pommier
Mitochondrial tyrosyl-DNA phosphodiesterase 2 and its TDP2S short isoform. EMBO reports 19 (3) (2018)
Shar-Yin N Huang, Jessica S Williams, Mercedes E Arana, Thomas A Kunkel, Yves Pommier
Topoisomerase I-mediated cleavage at unrepaired ribonucleotides generates DNA double-strand breaks. The EMBO journal 36 (3) (2016)