Prognostic value of histone H3 serine 10 phosphorylation and histone H4 lysine 12 acetylation in oral squamous cell carcinoma.

Esther Campos-FernándezFlavia S MatsuoMarília F AndradeJoão Paulo Silva ServatoAdriano M LoyolaSérgio Vitorino CardosoSindeval J SivaAlberto da S MoraesPaulo Rogério de Faria

Published in: Histopathology (2018)

These findings suggest that H3S10ph, and mainly H4K12ac, may play a role in OSCC progression and the occurrence of cervical lymph node metastasis. Also, the expression level of H4K12ac could be an independent prognostic factor for OSCC patients.

Keyphrases

prognostic factors
lymph node metastasis
end stage renal disease
squamous cell carcinoma
newly diagnosed
ejection fraction
poor prognosis
papillary thyroid
protein kinase
amino acid