TOP2A/MCM2, p16INK4a, and cyclin E1 expression in liquid-based cytology: a biomarkers panel for progression risk of cervical premalignant lesions.
Oscar Del Moral-HernándezDaniel Hernández-SoteloLuz Del Carmen Alarcón-RomeroMiguel Angel Mendoza-CatalánEugenia Flores-AlfaroYaneth Castro-CoronelJulio Ortiz-OrtizMarco Antonio Leyva-VázquezCarlos Ortuño-PinedaWendy Castro-MoraBerenice Illades-AguiarPublished in: BMC cancer (2021)
We propose that the detection of TOP2A/MCM2, p16INK4a and cyclin E1 expression levels is useful as a panel of biomarkers that allow identification of cervical lesions with a higher risk for progression to CC with high sensitivity and precision; this can be done inexpensively, in a single and non-invasive liquid-based cytology sample.