Single-nucleotide polymorphism rs1761667 in the CD36 gene is associated with orosensory perception of a fatty acid in obese and normal-weight Moroccan subjects.
Habiba BajitO Ait Si MohammedY GuennounS BenaichE BouaitiH BelghitiM MrabetE M ElfahimeN E El HalouiN SaeidK El KariA HichamiNaim Akhtar KhanH BenkiraneH AguenaouPublished in: Journal of nutritional science (2020)
Obese subjects have shown a preference for dietary lipids. A recent collection of evidence has proposed that a variant in the CD36 gene plays a significant role in this pathway. We assessed the association between the orosensory detection of a long-chain fatty acid, i.e. oleic acid (OA), and genetic polymorphism of the lipid taste sensor CD36 in obese and normal-weight subjects. Adult participants were recruited in the fasting condition. They were invited to fat taste perception sessions, using emulsions containing OA and according to the three-alternative forced-choice (3-AFC) method. Genomic DNA was used to determine the polymorphism (SNP rs 1761667) of the CD36 gene. Obese (n 50; BMI 34⋅97 (sd 4⋅02) kg/m2) exhibited a significantly higher oral detection threshold for OA (3⋅056 (sd 3⋅53) mmol/l) than did the normal-weight (n 50; BMI 22⋅16 (sd 1⋅81) kg/m2) participants (1⋅20 (sd 3⋅23) mmol/l; P = 0⋅007). There was a positive correlation between OA detection thresholds and BMI in all subjects; evenly with body fat percentage (BF%). AA genotype was more frequent in the obese group than normal-weight group. OA detection thresholds were much higher for AA and AG genotypes in obese subjects compared with normal-weight participants. Higher oral detection thresholds for fatty acid taste are related to BMI, BF% and not always to CD36 genotype.
Keyphrases
- weight loss
- fatty acid
- body mass index
- adipose tissue
- weight gain
- bariatric surgery
- metabolic syndrome
- loop mediated isothermal amplification
- genome wide
- type diabetes
- physical activity
- copy number
- label free
- knee osteoarthritis
- real time pcr
- obese patients
- insulin resistance
- nk cells
- young adults
- body weight
- blood pressure
- glycemic control
- sensitive detection
- circulating tumor cells
- skeletal muscle
- transcription factor