Altered blood gene expression in the obesity-related type 2 diabetes cluster may be causally involved in lipid metabolism: a Mendelian randomisation study.
Juliette A de KlerkJoline Wilhelma Johanna BeulensHailiang MeiRoel BijkerkAnton Jan van ZonneveldRobert Wilhelm KoivulaPetra J M EldersLeendert M 't HartRoderick C SliekerPublished in: Diabetologia (2023)
Multiple lncRNAs and mRNAs were found to be differentially expressed among clusters and particularly in the MOD cluster. mRNAs in the MOD cluster showed a possible causal effect on anthropometric traits, lipid metabolism traits and blood cell fractions. Together, our results show that individuals in the MOD cluster show aberrant RNA expression of genes that have a suggested causal role on multiple diabetes-relevant traits.