TGF-β1 inhibits human trophoblast cell invasion by upregulating kisspeptin expression through ERK1/2 but not SMAD signaling pathway.

Lanlan FangYang YanYibo GaoZe WuZhen WangSizhu YangJung-Chien ChengYing-Pu Sun

Published in: Reproductive biology and endocrinology : RB&E (2022)

By illustrating the potential physiological role of TGF-β1 in the regulation of kisspeptin expression, our results may serve to improve current strategies used to treat placental diseases.

Keyphrases

signaling pathway
transforming growth factor
poor prognosis
epithelial mesenchymal transition
pi k akt
endothelial cells
binding protein
long non coding rna
induced apoptosis
induced pluripotent stem cells