Body mass index as a determinant of clozapine plasma concentrations: A pharmacokinetic-based hypothesis.

Maxim KuzinEkkehard HaenChristoph HiemkeBenjamin BochonKarolina BochonGerhard GründerMichael PaulzenGeorgios Schoretsanitis

Published in: Journal of psychopharmacology (Oxford, England) (2021)

In obese patients, bioavailability, distribution or elimination of clozapine may be altered due to increased clozapine deposits in fat tissue and hepatic enzyme activity changes.

Keyphrases

obese patients
body mass index
bariatric surgery
gastric bypass
roux en y gastric bypass
adipose tissue
physical activity
weight loss
weight gain
fatty acid