High Prevalence of Bedaquiline Resistance in Treatment-Naive Tuberculosis Patients and Verapamil Effectiveness.
Hasan GhajavandMansour Kargarpour KamakoliSharareh KhanipourShahin Pourazar DizajiMorteza MasoumiFatemeh Rahimi JamnaniAbolfazl FatehSeyed Davar SiadatFarzam VaziriPublished in: Antimicrobial agents and chemotherapy (2019)
In the regions where bedaquiline (BDQ) is introduced into the regimen, analysis of MIC and screening for preexisting resistance mutations could be crucial. The high prevalence of isolates with high BDQ MICs without prior exposure to BDQ was worrisome. It was also concluded that efflux pumps play a pivotal role in intrinsic BDQ resistance; therefore, the potential of verapamil as an adjunctive therapy to combat BDQ resistance should be investigated.
Keyphrases
- multidrug resistant
- drug resistant
- end stage renal disease
- randomized controlled trial
- mycobacterium tuberculosis
- systematic review
- newly diagnosed
- ejection fraction
- chronic kidney disease
- prognostic factors
- emergency department
- hiv infected
- high resolution
- stem cells
- mesenchymal stem cells
- peritoneal dialysis
- patient reported outcomes
- human immunodeficiency virus
- bone marrow
- patient reported
- adverse drug
- drug induced