Smad7 interrupts TGF-β signaling in intestinal macrophages and promotes inflammatory activation of these cells during necrotizing enterocolitis.

Krishnan MohanKumarKopperuncholan NamachivayamKalyan C ChapalamaduguSteven A GarzonMuralidhar H PremkumarSrinivas M TipparajuAkhil Maheshwari

Published in: Pediatric research (2016)

Smad7 expression in NEC macrophages interrupts TGF-β signaling and promotes NF-κB-mediated inflammatory signaling in these cells through increased expression of IKK-β.

Keyphrases

transforming growth factor
induced apoptosis
poor prognosis
cell cycle arrest
oxidative stress
epithelial mesenchymal transition
signaling pathway
pi k akt
cell death
lps induced
long non coding rna
cell proliferation
low birth weight
preterm birth
inflammatory response