Changes in expression of the CD200 tolerance-signaling molecule and its receptor (CD200R) by villus trophoblasts during first trimester missed abortion and in chronic histiocytic intervillositis.

David A ClarkJennifer M DmetrichukElizabeth McCreadySukhbinder Dhesy-ThindJorge L Arredondo

Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2017)

Residual CD200 activity may prevent completion of abortions via induction of Treg cells. In CHI, infiltrating maternal effector T cells may block Treg induction. An autocrine role for CD200-CD200R interaction versus inhibition of soluble CD200 by soluble CD200R is discussed.

Keyphrases

nk cells
poor prognosis
induced apoptosis
oxidative stress
immune response
body mass index
pregnant women
physical activity
cell proliferation
regulatory t cells
long non coding rna
pi k akt