Non-celiac gluten or wheat sensitivity: It's complicated!
Maria I Pinto-SanchezElena F VerduPublished in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2019)
In the last 30 years, non-celiac gluten sensitivity (NCGS) has emerged as an intriguing and controversial topic in gastroenterology. The diagnosis of NCGS/NCWS requires a symptomatic reaction to gluten, or wheat-containing food, and remission of symptoms with gluten or wheat challenge, in patients in whom celiac disease and wheat allergy have been excluded. There have been several randomized clinical trials (RCT) addressing this issue which have produced controversial results. In this issue of Neurogastroenterology and Motility, a double-blind placebo-controlled randomized trial in patients with suspected NCGS on GFD, did not reproduce symptoms after gluten intake compared to placebo. This mini-review addresses outstanding issues related to the diagnosis of NCGS/NCWS as well as areas of interest for future studies that could explain, in part, the controversy in this area.
Keyphrases
- celiac disease
- end stage renal disease
- placebo controlled
- double blind
- ejection fraction
- chronic kidney disease
- newly diagnosed
- peritoneal dialysis
- randomized controlled trial
- sleep quality
- cystic fibrosis
- rheumatoid arthritis
- staphylococcus aureus
- risk assessment
- clinical trial
- human health
- pseudomonas aeruginosa
- disease activity
- physical activity
- ulcerative colitis
- atopic dermatitis
- irritable bowel syndrome
- phase ii study