Inhibition of chikungunya virus replication by N-ω-Chloroacetyl-L-Ornithine in C6/36, Vero cells and human fibroblast BJ.

Lucero Rojas-LunaAraceli Posadas-Modragón Amanda M Avila-TrejoVerónica Alcántara-FarfánLorena I Rodríguez-PáezJosé Angel Santiago-CruzMarvin O Pastor-Alonso José Leopoldo Aguilar-Faisal

Published in: Antiviral therapy (2023)

NCAO inhibits CHIKV replication by depleting the intracellular polyamines in Vero, C6/36 cells and human fibroblast BJ, suggesting that this compound is a possible antiviral agent for CHIKV.

Keyphrases

induced apoptosis
endothelial cells
cell cycle arrest
induced pluripotent stem cells
endoplasmic reticulum stress
zika virus
pluripotent stem cells
cell death
reactive oxygen species