IL-1β pre-stimulation enhances the therapeutic effects of endometrial regenerative cells on experimental colitis.

Dingding YuYiming ZhaoHongda WangDejun KongWang JinYonghao HuYafei QinBaoren ZhangXiang LiJingpeng HaoGuangming LiHao Wang

Published in: Stem cell research & therapy (2021)

This study has demonstrated that IL-1β pre-stimulation effectively downregulated DKK1 expression in ERCs, which in turn promoted the wnt/β-catenin pathway activation in colonic and splenic tissues. Consequently, IL-1β-primed ERCs exhibited an enhanced therapeutic effect in the attenuation of DSS-induced colitis.

Keyphrases

stem cells
induced apoptosis
poor prognosis
mesenchymal stem cells
gene expression
cell proliferation
ulcerative colitis
cell therapy
signaling pathway
long non coding rna
bone marrow