Pluronic micelles encapsulated curcumin manifests apoptotic cell death and inhibits pro-inflammatory cytokines in human breast adenocarcinoma cells.

Foram U VaidyaRakesh SharmaSofiya ShaikhDebes RayVinod K AswalChandramani Pathak

Published in: Cancer reports (Hoboken, N.J.) (2018)

This study suggests that Pluronic micelles encapsulated curcumin is stable that can effectively inhibit cell proliferation and release of pro-inflammatory cytokines in cancer cells as compared with the free curcumin. This approach could be applied to improve the therapeutic index of anti-cancer agents.

Keyphrases

cell death
cell cycle arrest
cell proliferation
drug delivery
anti inflammatory
induced apoptosis
endothelial cells
drug release
cancer therapy
squamous cell carcinoma
pi k akt
hyaluronic acid
oxidative stress
endoplasmic reticulum stress
pluripotent stem cells