MicroRNAs: Important Regulatory Molecules in Acute Lung Injury/Acute Respiratory Distress Syndrome.
Qianying LuSifan YuXiangyan MengMingyu ShiSiyu HuangJunfeng LiJianfeng ZhangYangfan LiangMengjun JiYanmei ZhaoHaojun FanPublished in: International journal of molecular sciences (2022)
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is an overactivated inflammatory response caused by direct or indirect injuries that destroy lung parenchymal cells and dramatically reduce lung function. Although some research progress has been made in recent years, the pathogenesis of ALI/ARDS remains unclear due to its heterogeneity and etiology. MicroRNAs (miRNAs), a type of small noncoding RNA, play a vital role in various diseases. In ALI/ARDS, miRNAs can regulate inflammatory and immune responses by targeting specific molecules. Regulation of miRNA expression can reduce damage and promote the recovery of ALI/ARDS. Consequently, miRNAs are considered as potential diagnostic indicators and therapeutic targets of ALI/ARDS. Given that inflammation plays an important role in the pathogenesis of ALI/ARDS, we review the miRNAs involved in the inflammatory process of ALI/ARDS to provide new ideas for the pathogenesis, clinical diagnosis, and treatment of ALI/ARDS.
Keyphrases
- acute respiratory distress syndrome
- extracorporeal membrane oxygenation
- mechanical ventilation
- oxidative stress
- lung function
- inflammatory response
- immune response
- lipopolysaccharide induced
- lps induced
- poor prognosis
- cystic fibrosis
- air pollution
- intensive care unit
- chronic obstructive pulmonary disease
- single cell
- dendritic cells
- induced apoptosis
- toll like receptor
- transcription factor
- long non coding rna
- risk assessment