Increased canonical NF-kappaB signaling specifically in macrophages is sufficient to limit tumor progression in syngeneic murine models of ovarian cancer.
Alyssa A HooverDemetra H HufnagelWhitney HarrisKennady BullockEvan B GlassEsther LiuWhitney BarhamMarta A CrispensDineo KhabeleTodd D GiorgioAndrew J WilsonFiona E YullPublished in: BMC cancer (2020)
In syngeneic ovarian cancer models, increased canonical NF-κB signaling in macrophages promoted anti-tumor TAM phenotypes and increased cytotoxic T cell infiltration, which was sufficient to limit tumor progression. This may present a novel translational approach for ovarian cancer treatment, with the potential to increase responses to T cell-directed therapy in future studies.