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Increased canonical NF-kappaB signaling specifically in macrophages is sufficient to limit tumor progression in syngeneic murine models of ovarian cancer.

Alyssa A HooverDemetra H HufnagelWhitney HarrisKennady BullockEvan B GlassEsther LiuWhitney BarhamMarta A CrispensDineo KhabeleTodd D GiorgioAndrew J WilsonFiona E Yull
Published in: BMC cancer (2020)
In syngeneic ovarian cancer models, increased canonical NF-κB signaling in macrophages promoted anti-tumor TAM phenotypes and increased cytotoxic T cell infiltration, which was sufficient to limit tumor progression. This may present a novel translational approach for ovarian cancer treatment, with the potential to increase responses to T cell-directed therapy in future studies.
Keyphrases
  • signaling pathway
  • poor prognosis
  • lps induced
  • oxidative stress
  • nuclear factor
  • stem cells
  • immune response
  • inflammatory response
  • toll like receptor
  • climate change
  • anti inflammatory